Medical and Health Sciences

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    Open Access
    Disruption of white matter integrity and its relationship with cognitive function in non-severe traumatic brain injury
    (10/11/2022) Aimi Nadhiah Abdullah, Asma Hayati Ahmad, Rahimah Zakaria, Sofina Tamam, Aini Ismafairus Abd Hamid, Wen Jia Chai, Hazim Omar2, Muhammad Riddha Abdul Rahman, Diana Noma Fitzrol, Zamzuri Idris, Abdul Rahman Izaini Ghani, Wan Nor Azlen Wan Mohamad, Faiz Mustafar, Muhammad Hafiz Hanafi, Mohamed Faruque Reza, Hafidah Umar, Mohd Faizal Mohd Zulkifly, Song Yee Ang, Zaitun Zakaria, Kamarul Imran Musa, Azizah Othman, Zunaina Embong, Nur Asma Sapiai, Regunath Kandasamy, Haidi Ibrahim, Mohd Zaid Abdullah, Kannapha Amaruchkul, Pedro Antonio Valdes-Sosa, Maria Luisa Bringas Vega, Bharat Biswal, Jitkomut Songsiri, Hamwira Sakti Yaacob, Putra Sumari, Nor Azila Noh, Azlinda Azman, Paramjit Singh Jamir Singh and Jafri Malin Abdullah
    Impairment in cognitive function is a recognized outcome of traumatic brain injury (TBI). However, the degree of impairment has variable relationship with TBI severity and time post injury. The underlying pathology is often due to diffuse axonal injury that has been found even in mild TBI. In this study, we examine the state of white matter putative connectivity in patients with non-severe TBI in the subacute phase, i.e., within 10 weeks of injury and determine its relationship with neuropsychological scores.
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    Open Access
    Contact-based temperature, breathing and cough patterns dataset for early COVID-19 symptoms identification
    (12/12/2021) Omer Ali; Mohamad Khairi Bhatti; Muhammad Kamran Liaquat
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    Open Access
    Repository Data Healthcare Cost Ver7.1
    (2/12/2021) Raman, Sivaraj
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    Open Access
    Geometric morphometric analysis of the first lumbar vertebra by 3D computed tomography for sex estimation in the Malaysian population
    (2/7/2022) Rohmani, Afiana; Faridah Mohd Nor; Mohamed Swarhib Shafee; Nik Azuan Nik Ismail; Helmi Hadi
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    Open Access
    Raw Data of Honey in Prophetic Medicine Manuscripts
    (Mendeley Data, 2019-07-19) Mohammad Amir Wan Harun
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    Open Access
    Dispersive liquid-liquid microextraction with extractant removal by magnetic nanoparticles for chloramphenicol preconcentration in water samples
    (Zenodo, 2020-03-20) Yahaya, Noorfatimah; Md Saad, Salwani; Aling, Nur Afiqah; Miskam, Mazidatulakmam; Saaid, Mardiana; Mohamad Zain, Nur Nadhirah; Kamaruzaman, Sazlinda; Raoov, Muggundha; Mohamad Hanapi, Nor Suhaila; Wan Ibrahim, Wan Nazihah
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    Open Access
    SCNS-SF34Malay dataset
    (Mendeley Data, 2021-04-19) Mohd Shariff, Noorsuzana; Azman, Nizuwan
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    Open Access
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    Metadata only
    Escherichia coli strain INF32/16/A: Dataset of raw reads and assembled draft genome
    (Elsevier, 2021-06-11) Shuhaila Mat-Sharani; Suhaila Sulaiman; Nik Yusnoraini Yusof
    Escherichia coli strain INF32/16/A is a gram-negative bacteria which is an extended-spectrum beta-lactamases (ESBL). ESBL is an enzyme that is produced by bacteria to become resistant to existing antibiotic such as extended-spectrum penicillin, cephalosporins, and have been threatening the ability to treat an infection. Therefore, genome analysis will provide an insight of how this bacteria able to evolve and the information obtained will able to facilitate in designing new antibiotics. The genome of E. coli strain was sequenced using Illumina MiSeq and raw genome sequence have been submitted into NCBI SRA database (SRR15334628) under Bioproject accession number PRJNA726861.
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    Metadata only
    Curation of an international drug proprietary names dataset
    (Elsevier, 2021-11-22) Mohammad A. Khaleel; Amer Hayat Khan; S.M. Sheikh Ghadzi; Sami Alshakhshir
    A drug dataset containing international proprietary names is essential for researchers investigating different drugs from different countries worldwide. However, many websites on the internet offer free access for a single drug searching service to identify international drug trade names, but not for a list of drugs to be searched and identified. Therefore, it will be problematic if the researcher has a list of hundreds or thousands of drug trade names to be identified. In this project, we have created an International Drug Dictionary (IDD) by curating collected drug lists from open access websites belonging to official drug regulatory agencies, official healthcare systems, or recognized scientific bodies from 44 countries around the world in addition to the European public assessment reports (EPAR) and the DRUGBANK vocabulary published in the public domain. Researchers interested in pharmacovigilance, pharmacoepidemiology, or pharmacoeconomics can benefit from this dataset, especially when identifying lists of proprietary drug names, particularly of multi-national origin. To enhance its adaptability, we also mapped the IDD to the standardized drug vocabulary RxNorm. The IDD can also be used as a tool for mapping international drug trade names to RxNorm. Each drug entity in the IDD mapped to a unique identification number for each entity called Atom Unique Identifier (RXAUI) from RxNorm.
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    Open Access
    Microembolus Signal using Trancranial Doppler Ultrasound (TCD) Simulator
    (Mendeley Data, 2022-04-12) Najah Ghazali; Dzati Athiar Ramli
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    Genome sequencing data of extended-spectrum beta-lactamase-producing Escherichia coli INF191/17/A isolates of nosocomial infection
    (Elsevier, 2022-06-23) Nik Siti Hanifah Nik Ahmad; Khor Bee Yin; Nik Yusnoraini Yusof
    The infection with extended-spectrum beta-lactamase-producing Escherichia coli is associated with higher mortality, longer length of hospital-stay and increased costs compared to infection with antibiotic-susceptible E. coli. Here, the draft genome of ESBL-producing E. coli circulating at local hospital is reported. The strain was detected as containing the genes of antibiotic resistance TEM, CTX-M-1, and CTX-M-9. The 5,136,548-bp genome, with a GC content of 50.59%, comprised 4987 protein-coding genes, four ribosomal RNA, and 66 transfer RNA. The ResFinder was successfully predicted fourteen antimicrobial genes in the E. coli INF191/17/A genome. Sequence data has been deposited in the GenBank database under the accession number JAIEXV000000000. The BioProject ID in the GenBank database is PRJNA752944. The raw data was sequenced using Ilumina MiSeq and submitted to the NCBI SRA database (SRX11797310), which is publicly available.
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    Open Access
    Stingless bee propolis, metformin, and their combination alleviate diabetic cardiomyopathy
    (2022-07-02) Oon Zhi Lim; Boon Seng Yeoh; Norsuhana Omar; Mahaneem Mohamed; Anani Aila Mat Zin; Rozaziana Ahmad
    Background and aim: Stingless bee propolis, a resinous compound processed by mandibular secretion of stingless bees, is used for maintenance of hygiene and stability of beehives. Research on stingless bee propolis shows therapeutic properties attributed to polyphenols exhibiting antioxidative, antihyperglycemic and antiischemic effect. However, the cardioprotective effect of stingless bee propolis on diabetic cardiomyopathy is unknown. Methods: Adult male Sprague Dawley rats were randomised to five groups: normal group, diabetic group, diabetic given metformin (DM+M), diabetic given propolis (DM+P) and diabetic given combination therapy (DM+M+P) and treated for four weeks. Body weight, fasting blood glucose, food and water intake were taken weekly. At the end of experiment, biomarkers of oxidative damage were measured in serum and heart tissue. Antioxidants in heart tissue were quantified. Part of left ventricle of heart was processed for histological staining including Haematoxylin and Eosin (H&E) stain for myocyte size and Masson’s Trichrome (MT) stain for heart fibrosis and perivascular fibrosis. Results: Propolis alleviated features of diabetic cardiomyopathy such as myocyte hypertrophy, heart fibrosis and perivascular fibrosis associated with improvement in antioxidative status. Conclusion: This study reports beneficial effect of propolis and combination with metformin in alleviating histopathological feature of diabetic cardiomyopathy by modulating antioxidants, making propolis an emerging complementary therapy.
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    Open Access
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    Small RNA datasets of drug-susceptible Mycobacterium tuberculosis strains from Sabah, Malaysia
    (Elsevier, 2022-11-29) Mohd Iskandar Jumat; Jaeyres Jani; Zainal Arifin Mustapha; Rodrigues, Kenneth Francis; Armando Acosta; Maria E. Sarmiento; Kai Ling Chin
    These datasets present a list of small RNAs from three drug-susceptible Mycobacterium tuberculosis strains isolated from Sabah, Malaysia. Sputum samples were obtained from three tuberculosis patients belonging to different districts. The bacteria were detected using GeneXpert MTB/RIF, isolated and cultured in BACTECTM MGITTM 320, and tested for their drug susceptibility. Total RNAs were extracted, sequenced, and analyzed using bioinformatic tools to filter out small RNA present in the Mycobacterium tuberculosis strains. Small RNA sequencing generated total raw reads of 63,252,209, 63,636,812, and 61,148,224 and total trimmed reads (15-30 nucleotides) of 51,533,188, 53,520,197, and 51,363,772 for Mycobacterium tuberculosis strain SBH49, SBH149, and SBH372, respectively. The raw data were submitted to the Sequence Read Archive (SRA) database of the National Center for Biotechnology Information (NCBI) under the accession numbers of SRX16744291 (SBH49), SRX16744292 (SBH149), and SRX16744293 (SBH372). Small RNAs play important roles in cellular processes such as cell differentiation, cell signaling, development of resistance to antibiotics and immune response, and metabolism regulation. The small RNAs determined here could provide further insights into various cellular processes crucial for Mycobacterium tuberculosis survivability and a better understanding of their gene regulation which ultimately opens a new pathway for combating tuberculosis infection.
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    Open Access
    Raw data-Predictors of tuberculosis in smokers
    (3/13/2022) Nik Husain, Nik Rosmawati
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    Open Access
    Global endothelial function assessment using pulse wave analysis in hypercholesterolemia
    (7/14/2022) Nik Ibrahim, Nik Nor izah; Abdul Rahman, Razlina; Azlan, Maryam; Ghulam Rasool, Aida Hanum
    To compare global endothelial function assessed by pulse wave analysis (PWA) using the ratio of endothelium dependent vasodilatation (EDV) to endothelium independent vasodilatation (EIV) in patients with hypercholesterolemia and controls. 92 subjects [46 hypercholesterolemics, 46 controls] were studied at standardized conditions. Baseline augmentation index (AIx) was assessed followed by the administration of 0.5 mg sublingual nitroglycerine, an endothelium independent vasodilator. AIx was assessed and the maximum change in AIx after nitroglycerine was recorded as EIV. After a washout period of 30 minutes, 400 µg of inhaled salbutamol, an endothelium dependent vasodilator was administered. AIx was assessed again and the maximum change in AIx after salbutamol was recorded as EDV. Global endothelial function was calculated as EDV:EIV ratio. EDV and EIV in patients with hypercholesterolemia compared to controls were 2.97 ± 3.95 and 6.65 ± 3.80 (p<0.001); and 13.41 ± 4.57 and 15.88 ± 4.78 (p=0.01) respectively. EDV:EIV ratio was significantly reduced in patients with hypercholesterolemia compared to controls; 0.21 ± 0.38 and 0.44 ± 0.24 (p<0.001) respectively. EDV:EIV ratio was significantly reduced in patients with hypercholesterolemia compared to controls. PWA is a potential clinical tool to assess global endothelial function in patients with hypercholesterolemia.
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    Open Access
    Influence of KCNH2 Polymorphisms on the QTc Interval in Kelantanese Malays Patients Receiving Methadone Maintenance Therapy (MMT) in Malaysia
    (7/19/2018) Abdul Jalal, Muhammad Irfan; Muslih AbdulKarim Ibrahim; Nasir Mohamad; Nurfadhlina Musa; Rusli Ismail; Zalina Zahari
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    Open Access